A metanalysis to assess the independent and combined association of low eGFR and albuminuria with mortality is just published in Lancet (CKD Prognosis Consortium, Lancet, May 2010). In this well-conducted study, data from about 1.2 million participants from 21 eligible studies were analyzed. Median follow up was about 8 years. It was found that mortality was lowest with eGFR between 105 and 75 ml/min, and rose exponentially as eGFR decreased with statistical significance for eGFR below 60 ml/min. In regards to albuminuria, the risk was linear with significance starting at albumin/creatinine ratio of 10 mg/g (which is well below the microalbuminuric range of 30-300) or more. Risk was multiplicative when both eGFR and albuminuria were plotted together. Authors propose to use both these measures for risk assessment and CKD staging.
No comments:
Post a Comment